Conclusions

Slide 20 of 21

Notes:

1. Higher charge on H-CD vs. ds 1

2. Sulfated CDs move slower, greater m/z ratio

3.CDCE is effective

4. Although I am not presenting data to support this, we experienced great run to run irreproducibility with sulfated CD’s. Attribute to interactions of sulfated CD with capillary wall

Not as bad with H-DMCH-b-CD

1. Lower window of elution (migrates slower, K values lower?)

2. H-DMS and b-Cd not acting independently when in running buffer.

3. CDCE becomes unpredictable Can not rationally design mixtures of CDs to separate analytes.

H-DAS performance on these separations was intermediate of thes two described above.